Relationship of Chronic Urticaria with Helicobacter pylori infection

Abstract

Introduction: Spontaneous chronic urticaria develops without an apparent trigger, but some infections are associated with exacerbation of symptoms, such as infections caused by Helicobacter pylori.

Objective: To determine the relationship between the presence of chronic urticaria and Helicobacter pylori infection.

Methods: A cross-sectional analytical study was carried out in the Dermatology Service at Manuel Fajardo Clinical Surgical University Hospital from March to December 2018. The sample consisted of 32 patients diagnosed with chronic urticaria, who attended the dermatology consultation of the hospital, in this period, according to the non-probabilistic selection criteria of the investigator.

Results: 34.4% corresponded to patients between 49 and 58 years of age. Twenty of them had Helicobacter pylori infection and the female sex was the most affected. Pruritus prevailed in 100% of the patients. The serological study was positive for Helicobacter pylori in all cases. There was control of the disease in 40% of the cases after the treatment of the bacteria.

Conclusions: Helicobacter pylori can stimulate the immune response with production of inflammatory cytokines, which is related to chronic urticaria. IgG and Immunochromatography constituted a tool for the diagnosis of the bacterium.